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[20] A 2015 review found "Avoiding withdrawal symptoms is one of the causes of continued smoking or relapses during attempts at cessation, and the severity and duration of nicotine withdrawal symptoms predict relapse." [23] Symptoms of nicotine dependence include irritability, anger, impatience, and problems in concentrating

The surveyor's documentation was presented to the Secretary of the colony, who then issued a patent (also known as a grant)

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Effects of N-nitrosonornicotine and N-nitrosoanabasine in Syrian golden hamsters